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Modern Applications in Pharmacy & Pharmacology

Diabetic Peripheral Neuropathy: Therapeutic Options

  • Open or Close Tapas Kumar Sur1* and Anjan Adhikari2

    1Department of Pharmacology, IPGME&R & SSKM Hospital, India

    2Department of Pharmacology, RG Kar Medical College, India

    *Corresponding author: Tapas Kumar Sur, Post Doctoral Research Scholar, Department of Pharmacology, Institute of Post Graduate Medical Education & Research & SSKM Hospital, Govt. of West Bengal, 244B, AJC Bose Road -700 020, West Bengal, India

Submission: October 31, 2017; Published: January 24, 2018

DOI: 10.31031/MAPP.2018.01.000512

ISSN 2637-7756
Volume1 Issue3


Diabetes poses neurological damages and result in diabetic peripheral neuropathy (DPN). The prevalence of DPN varies from 10-90%. The persistent hyperglycemia, microvascular insufficiency, oxidative and nitrosative stress, defective neurotrophism, and autoimmune nerve destruction are the important factors of DPN. Peripheral nerve conduction velocities (NCV) are considered one of the most sensitive indices of the severity of neuropathy in DPN. Control of hyperglycemia is only the best treatment exists for DPN. Besides glucose lowering therapy, antidepressants, anticonvulsants, opioid analgesics, anti arrhythmics, and NMDA receptor antagonists are commonly used, though all these drugs have adverse actions. Recent researches are focused on the development of neurotrophic factors (NTFs), nitrate sprays and topical capsaicin for the treatment of DPN.

Keywords: Diabetes; Diabetic peripheral neuropathy; Nerve conduction velocity; Neurotrophic factors; Nitrate sprays; Topical capsaicin

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