Triazine Based Porous Organic Polymers

1,3,5-triazines represents a widely used lead structure with a multitude of interesting applications in numerous fields. As per Anupama et al. [1] Triazine is a well-known compound in organic chemistry and has been used in a variety of applications as its 2,4,6-mono-, di- or trisubstituted derivatives bearing different substituents. As per them, Triazine is a prototypal molecule that has together with its derivatives wide commercial use, for example, in resins, dyes, herbicides, or as sulfide removal agents.

Triazine-based Covalent Organic Polymers (COPs) constructed from triazine or nitrilecontaining precursors via covalent bonding are becoming an important sub-class of porous organic framework materials for a range of applications. support material for a variety of liquid phase organic transformation reactions owing to their tunable porous structures with high surface area, high nitrogen contents, high stability in both organic and aqueous media, and relatively easy synthesis [1-3].

Osman et al. [3] Synthesized 2,4-Dichloro-6-substituted s-triazine was reacted with 1,4-diamino butane followed by the addition of triethylamine as an HCl scavenger (Scheme 1). For comparative studies, the polymers were prepared using both conventional and microwave heating methods. It’s a unique porous structure of the Nano-Covalent Triazine Polymer (NCTP) containing Aggregation-Induced Emission (AIE) group to achieve controlled release and drug tracking in tumor acidic microenvironment. NCTP was synthesized by the Friedel-Crafts alkylation and the McMurry coupling reaction. It not only had strong Doxorubicin (DOX)- loading capacity due to its high specific surface area and large pore volume but also showed significant cumulative drug release as a result of the pH response of triazine polymers.

Aldalbahi et al. [4] Synthesized and characterized two types of polymer-based s-triazine bis hydrazine and bishydrazido derivatives and applied them as charring agents together with APP (as acid source) to build an IFR system that could develop the thermal degradation performance of Polypropylene. Biljan et al. Reported the synthesis and characterization of new Two-Dimensional (2D) benzene- and triazine-based azo-bridged porous organic polymers [4- 7]. The prepared polymers are all amorphous solids of good thermal stability, with the highest thermal stability observed for triazine-based Yun Suk et al. introduced a microporous Covalent Triazine Polymer (CTP) network with a high surface area was synthesized via the Friedel– Crafts reaction and employed as a potential transport system for drug delivery and controlled release. The CTP was transformed to the nanoscale region by intense ultrasonication followed by filtration to yield Nanoscale CTP (NCTP). Khattab et al. [8] Report on the synthesis of a library of new s-triazine polyamides containing glycine and thioglycolic acid. The feasibility of the synthesized polymers as drug nano-delivery systems was investigated. The nanoparticles were loaded with Celecoxib (CXB), an anti-inflammatory drug with a highly promising anti-cancer effect, resulting in high entrapment efficiency levels.

1. Anupama, Iram Khan, Bhawani Singh (2016) Synthesis of biologically important s‐triazine based chalcones. IJPSR 6(8): 3209-3214.
2. Singh, Anupama, Kumari, Sukhbeer (2022) Synthesis of triazine based dendrimers: A Mini review. Mini-Reviews in Organic Chemistry 19(5): 569-574.
3. Osman SM, Khattab SN, Aly (2017) 1,3,5-Triazine-based polymer, synthesis, characterization and application for immobilization of silver nanoparticles. J Polym Res 24(231).
4. Ali Aldalbahi, Bander SA, Badr MT, Ayman EF (2022) Synthesis of new s-triazine bishydrazino and bishydrazido-based polymers and their application in flame-retardant polypropylene composites polymers. Polymers (Basel) 14(4): 784.
5. Barbara P, Tea F, Mladen B, Kristian K, Miro S, et al. (2023) Synthesis and characterization of benzene- and triazine-based azo-bridged porous organic polymers. polymers 15(1): 229.
6. Yun Suk, introduced a microporous Covalent Triazine Polymer (CTP) network with a high surface area was synthesized via the friedel–crafts reaction and employed as a potential transport system for drug delivery and controlled release. The CTP was transformed to the nanoscale region by intense ultrasonication followed by filtration to yield nanoscale CTP (NCTP).
7. Sherine N, Samar EA, Mousa ES, Aly B, Adnan A, et al. (2016) Design and synthesis of new s-triazine polymers and their application as nanoparticulate drug delivery systems. New J. Chem 40: 9565-9578.
8. Khattab, reports the synthesis of a library of new s-triazine polyamides containing glycine and thioglycolic acid. The feasibility of the synthesized polymers as drug Nano delivery systems was investigated. The nanoparticles were loaded with celecoxib (CXB), an anti-inflammatory drug with a highly promising anti-cancer effect, resulting in high entrapment efficiency levels.