Abstract

Flutamide is a toluidine derivative that acts as an antiandrogen and binds to the androgen receptor, thereby inhibits the action of testosterone. This study was done on flutamide to analyze the outcome of the Trivedi Effect®-Consciousness Energy Healing Treatment on its various physicochemical and thermal properties. For this, the sample was divided into two parts and named as the control and treated sample. No treatment was given to the control part, while the treated part was received the Trivedi Effect® -Biofield Energy Healing Treatment, remotely by a renowned Biofield Energy Healer, Gopal Nayak. The experimental results revealed the significant reduction in the particle size values by 3.35% (d10), 4.95% (d50), 10.75% (d90), and 8.91% {D (4, 3)}; thereby, the specific surface area was increased by 5.32% in the treated sample compared to the control sample. The powder XRD peak intensities and crystallite sizes were significantly altered in the in the range from -50.66% to 30.17% and -50.56% to 86.54%, respectively; thus, the average crystallite size was significantly reduced by 11.82% in the treated flutamide compared with the control sample. The residue weight was reduced in the treated sample by 19.88%; whereas, the maximum thermal degradation temperature was decreased by 2.38% in the treated flutamide compared to the control sample. The latent heat of fusion of the treated flutamide was significantly increased by 9.84% compared to the control sample. The overall results indicated the significant change in the particle size, crystal properties, and thermal stability of the treated sample after the Biofield Energy Treatment as compared to the untreated sample, which might be due to the possible formation of a novel polymorph. Hence, the Biofield Energy treated flutamide sample might help in developing its pharmaceutical formulation with improved solubility, absorption, and bioavailability that might improve its performance against various diseases, i.e., prostate cancer, androgen-dependent skin and hair conditions including acne, seborrhea, hirsutism, and scalp hair loss, hyperandrogenism, as well useful for feminizing hormone therapy aimed at transgender women.

Keywords: Complementary and Alternative Medicine, Flutamide, The Trivedi Effect®, Energy of Consciousness Healing Treatment, PSA, PXRD, TGA, DSC