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Abstract

Journal of Biotechnology & Bioresearch

Genetic Processes in Eukaryotic Cells-A Cooperative Function Between Chromosomes and Extrachromosomal Circular DNA - and more?

  • Open or CloseReinhard H Dennin*

    Formerly: Academic Director, Head of Virology, Retd., Department of Infectious Diseases and Microbiology, University of Lübeck, UKSH, Campus Lübeck, Germany

    *Corresponding author:Reinhard H Dennin, Formerly: Academic Director, Head of Virology, Retd., Department of Infectious Diseases and Microbiology, University of Lübeck, UKSH, Campus Lübeck, Germany

Submission: July 19, 2021; Published: August 23, 2021

Abstract

Apart from chromosomal DNA and mitochondrial DNA, eukaryotic cells contain Extrachromosomal Circular DNA (ECC-DNA). The ECC-DNA sequences are derived from chromosomal DNA. Their sizes range from some thousand bp up to mega bp. Their proportion of total cellular DNA can be up to 20%, both in cells from healthy people and people suffering from, e.g., tumors. Only recently have these ECC-DNAs gained attention in the context of diseases. A particular focus targets their involvement in oncology. The possible influence of ECC-DNA on chromosomal sequences in the Human Genome Project is addressed.

Keywords: Extrachromosomal Circular (ECC) DNA; Genetics; Diagnostic reservoir; Human genome

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