Abstract

Given the intricate physiological processes involved, creating bone grafts or prosthetic implants for clinical use can be challenging. Fortunately, recent advancements in nanotechnology have accelerated and facilitated the development of functional bone grafts and implants. Rare Earth (RE) materials are a class of emerging biomaterials that possess unique properties such as biocompatibility, fluorescence upconversion, and anti-inflammatory effects, making them highly valuable in tissue engineering. Recently, there has been an increasing need for materials that can enhance tissue regeneration and advance our knowledge of bone restoration over extended periods of time. This study offers a novel technique for creating tunable green and yellow upconversion composite emissions by embedding lanthanide nanoparticles YAG:Ce3+ in Poly(Vinyl Alcohol) (PVA) scaffolds and stimulating them with 400nm blue wavelength light. By combining upconversion lanthanide nanoparticles with image superposition methodology, we are able to reliably track implanted materials or scaffolds over time during long-term fluorescence surveillance. This novel approach provides an effective way to distinguish between different materials and monitor their behavior in vitro and in vivo.

Keywords:Rare earth materials; Upconversion; Composite; Long-Term fluorescence; Poly(Vinyl Alcohol) (PVA)