Abstract

Recently, much attention has been focused on pharmacological agents that target the incretin axis due to the efficacy in reducing body weight and glycemia in adults and youth with overweight and obesity. However, much less focus has been placed on the endogenous secretion of the incretin hormones. In the present mini review, we examine studies that assessed the incretin changes in response to either diet or exercise intervention, in adults and youth with overweight and/or obesity. The types of intervention could differently impact on changes in incretin hormones as exercise studies consistently showed increase in incretin hormones while the findings from the diet studies were controversial.

Keywords:Lifestyle; Incretin; GLP-1; GIP; Obesity

Abbreviations:AUC: Area Under the Curve; GIP: Gastric Inhibitory Polypeptide; GLP-1: Glucagon-Like Peptide-One; MMT: Mixed Meal Tolerance Test; OGTT: Oral Glucose Tolerance Test; T2D: Type 2 Diabetes