1Dept. of Nephrology,
2‘Victor Babes’ University of Medicine and Pharmacy Timisoara, Romania
3County Emergency Hospital Timisoara, Romania
4Centre for Molecular Research in Nephrology and Vascular Disease, Romania
5Center for translational Research and Systems Medicine, Romania
6Center for Cognitive Research in Neurologic and Psychiatric Disease,Romania
*Corresponding author:Oana Milas, Assistant Professor, Department of Nephrology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania
Submission: December 23, 2020Published: January 21, 2021
ISSN : 2578-0263Volume4 Issue5
Over the last 20 years, most of the studies regarding the kidney outcome of people with solitary kidney (SK) show that there is a progressive loss of renal function in these individuals. In order to carry out the renal work undertaken by two kidneys, SK must adapt through complex phenomena of hypertrophy and hyperfiltration. The adaptive changes are considered, “the first hit” of SK because these lead to glomerular injury with progressive loss of kidney function. Thus, more than 50% of children with congenital SK have markers of renal injury by the age of 18 years. Also, living kidney donors have 3 to 5 times higher relative risk of end stage renal disease (ESRD as compared with their counterparts with two kidneys. A “second hit”, such as obesity, hypertension, and diabetes mellitus (DM), which superimpose to the SK status conducts to a faster decline in kidney function and to a poor renal prognosis of these individuals. Due to the fact that type 2 DM is a pandemic disease of the 21st century, with an increasing prevalence among SK patients, in this paper we aimed to present different patterns of the inter-relation between SK and DM.
Keywords:Acquired solitary kidney; Congenital solitary kidney;Diabetes mellitus;Living kidney donors
Abbreviations: ASK: Acquired Solitary Kidney; CKD: Chronic Kidney Disease; CSK: Congenital Solitary Kidney; DM: Diabetes Mellitus; ESRD: End Stage Renal Disease; LKD: Living Kidney Donor; SK: Solitary Kidney; UNX: Uninephrectomy