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Interventions in Obesity & Diabetes

Overview of Therapies for Diabetic Macular Edema

  • Open or CloseGabriela YCM1,2*, Italia A Rivera1,3, Gustavo AA1,2, Adrian Heald4,5 and Tania VS1

    1Hospital Regional de Alta Especialidad de Ixtapaluca, State of Mexico, Mexico

    2School of Medicine, Instituto Politécnico Nacional, Mexico City, Mexico

    3Centro Interdisciplinario de Ciencias de la Salud, Unidad Milpa Alta, Instituto Politécnico Nacional, Mexico City, Mexico

    4The School of Medicine and Manchester Academic Health Sciences Centre, United Kingdom

    5Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, United Kingdom

    *Corresponding author:Gabriela YCM, Hospital Regional de Alta Especialidad de Ixtapaluca, Zoquiapan, Ixtapaluca, Estado de Mexico, Mexico

Submission: June 04, 2019Published: June 14, 2019

DOI: 10.31031/IOD.2019.03.000552

ISSN : 2578-0263
Volume3 Issue1


Diabetic retinopathy is the most common microvascular complication of diabetes mellitus. The direct cause of this irreversible loss of sight is diabetic macular edema, which affects more than 126 million people worldwide. In order to confirm the diagnosis, specific studies, such as fluorescein angiography and optical coherence tomography (OCT), should be carried out to determine the degree and type of edema. We review recent efficacy and safety data for the therapies currently existing to reduce progression and recover vision in Diabetic Macular Edema. In addition, there is the high cost of treatment of macular edema, as well as the risks involved in the application of drugs used for this disease. We therefore decided to carry out this review in order to evaluate the effectiveness of different therapies for the management of diabetic macular edema. The growing controversy over treatment for this complication has led to a constant conflict over what the best therapeutic option for the affected individuals is. Alternatives for supplementation have also been sought out with studies that support the efficacy of their use in treating this disease.

Keywords: Anti-VEGF; Diabetic Retinopathy; Lutein; Macular Edema; Oxidative-Stress; Therapies

Abbreviations: OCT: Optical Coherence Tomography; DR: Diabetic Retinopathy; DME: Diabetic Macular Edema; VEGF: Vascular Endothelial Growth Factor; DRCR: Diabetic Retinopathy Clinical Research; ILM: Internal Limiting Membrane

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