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Interventions in Obesity & Diabetes

Cross-Talk Between Obesity and Central Nervous System: Role in Cognitive Function

  • Open or CloseSousa RAL*, Freitas DA and Leite HR

    Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Brazil

    *Corresponding author:Ricardo Augusto Leoni de Sousa, Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Centro Integrado de Pós- Graduação e Pesquisa em Saúde-CIPq- Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Brazil

Submission: April 04,2019Published: June 11, 2019

DOI: 10.31031/IOD.2019.03.000551

ISSN : 2578-0263
Volume3 Issue1


Obesity is a world health problem. Excess of white adipose tissue (WAT) might lead to development of neurodegenerative disorders. WAT contributes to low-grade inflammation leading to the enhancement of pro-inflammatory adipokines, such as TNF-α, leptin and IL-6, which will lead to a peripheral inflammation that affects central nervous system functioning. Pro-inflammatory adipokines are enhanced in obesity, while anti-inflammatory, such as IL-10 and adiponectin, are reduced. Obesity seems to be related to cognitive decline and the development of neurodegenerative diseases, such as dementia and Alzheimer, through the production of pro-inflammatory adipokines with a consistent reduction of adiponectin and IL-10.

Keywords:Obesity; Inflammation; Leptin; Brain regions; Cognitive performance

Abbreviations:WAT: White Adipose Tissue; TNF-α: Tumor Necrosis Factor Alpha; IL: Inter Leukin; CNS: Central Nervous System; BBB: Blood Brain Barrier

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