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Interventions in Obesity & Diabetes

Lysophosphatidic Acid: A Key Player in Obesity

Submission: February 19, 2019Published: April 25,2019

DOI: 10.31031/IOD.2019.02.000547

ISSN : 2578-0263
Volume2 Issue4


In an obese individual, elevated levels of no esterified fatty acids, glycerol, hormones, cytokines, proinflammatory substances, and other substances have been observed. Adipokine, autotoxin (ATX) released by adipocytes exerts a paracrine control over adipogenesis via LPA production which in turn aggravates obesity and insulin resistance in affected individuals. Obesity and its associated disorders (glucose homeostasis and cardiovascular disease like atherosclerosis) show an upregulated expression of ATX- LPA, which makes it a druggable target to treat obesity. In this review we have highlighted the role of lysolipid, LPA and its receptors in obesity and associated anomalies.

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