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Abstract
Interventions in Obesity & Diabetes
Lysophosphatidic Acid: A Key Player in Obesity
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Open or Close Saima SM1 Hina FB2* and Zuhaib FB3*
1 Department of Biotechnology, India
2 Division of Animal Biotechnology, India
3 Department of Food Sciences, New Zealand
*Corresponding author:Hina FB, Division of Animal Biotechnology, India
Submission: February 19, 2019Published: April 25,2019
ISSN : 2578-0263Volume2 Issue4
Abstract
In an obese individual, elevated levels of no esterified fatty acids, glycerol, hormones, cytokines, proinflammatory substances, and other substances have been observed. Adipokine, autotoxin (ATX) released by adipocytes exerts a paracrine control over adipogenesis via LPA production which in turn aggravates obesity and insulin resistance in affected individuals. Obesity and its associated disorders (glucose homeostasis and cardiovascular disease like atherosclerosis) show an upregulated expression of ATX- LPA, which makes it a druggable target to treat obesity. In this review we have highlighted the role of lysolipid, LPA and its receptors in obesity and associated anomalies.
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