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Abstract

Interventions in Obesity & Diabetes

In Vitro Radical Scavenging Activity and Modulating Effect of Annona Cherimola on Complications Associated With Diabetes in Experimental Diabetic Rats-An Approach to Evaluate Asymmetrical Temperature Distribution Analysis Using Thermography

Submission: March 27, 2018; Published: June 26, 2018

DOI: 10.31031/IOD.2018.01.000522

ISSN : 2578-0263
Volume1 Issue5

Abstract

The present research explores the traditional usage of Annona cherimola and validates its usage experimentally against diabetic complication and oxidative stress. Results of proximal constituents illustrated higher ash content (89.6%) representing edible nature and contains required amount of micro and macronutrients. In vitro α amylase inhibition assay with 26-57% inhibition justifies the usage of Annona cherimola to combat diabetes, further treatment with Annona cherimola extract to alloxan induced diabetic rats showed significant activity against diabetes by regulating the release of Insulin (46-159%), C-peptide (61-72%), maintaining the levels of GHb (1-28/%) and atherogenic index. Similarly, the altered renal (urea, uric acid and creatinine) and liver markers (SGOT, SGPT and ALP) was significantly reverted back to near normal levels after treatment. Meanwhile, enzymatic antioxidant (SOD, CAT) levels demonstrated the improvement in radical scavenging potential in liver and kidney tissues of diabetic rats after treatment. An attempt is made to understand the relationship between physiological responses associated with regulation of body temperature using animal surface temperature images captured with infrared camera. Whole body asymmetrical temperature distribution analysis results revealed significant temperature change in experimental animals with 1 to 5% carried out in abdominal area and observed reduction in temperature during treatment.

Keywords: Diabetes; Antioxidant; Body temperature; Annona cherimola; Thermography

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