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Abstract

Interventions in Obesity & Diabetes

Antihyperglycemic and Anti-hyperlipidemic Effect of Herbamed, A Herbal Formulation in Alloxan-Induced Diabetic Rats

  • Open or Close Isitua CC1*, Akinyemi AJ2, Akharaiyi FC1, Olubiyi OO3, Anadozie SO2 and Olayide II2

    1Department of biological sciences, Afe Babalola University Ado-Ekiti, Nigeria

    2Department of Chemical Sciences, Afe Babalola University Ado-Ekiti, Nigeria

    3Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti, Nigeria

    *Corresponding author: Isitua Chinwe Christy, Department of Biological Sciences, College of Sciences, Afe Babalola University Ado-Ekiti (ABUAD),Ekiti State, Nigeria

Submission: March 14, 2018; Published: May 18, 2018

DOI: 10.31031/IOD.2018.01.000519

ISSN : 2578-0263
Volume1 Issue4

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and its occurrence is increasing fast in most of the countries. Herbal medicine derived from plant extracts have been utilized increasingly for the treatment of various disorders like diabetes mellitus. The present study was designed to evaluate the anti diabetic activity of ‘Herbamed’, a herbal formulation composed of Vernonia amygdalina, Ocimum gratissimum, Zingiber officinale and Allium sativum in alloxan-induced diabetic rats model. Alloxan (150mg/kg) was used to induce diabetes in rats and the blood glucose levels were estimated by using glucometer. The herbal formulation known as ‘Herbamed’ was administered to diabetic rats for 7 days at 0.5 and 1.0mL (250mg/kg rat). The herbal formulation produced a significant reduction (P<0.05) of blood glucose levels in diabetic rats at both doses tested. It also showed a beneficial effect on the lipid profile and liver function test in alloxan induced diabetic rats. These results showed that ‘Herbamed’ exhibits antihyperglycemic and antihyperlipidemic activities in diabetic rats.

Keywords: Diabetes mellitus; Herbal medicine; Antihyperglycemic; Alloxan; Antihyperlipidemic

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