1Department of Internal Medicine, University of California, USA
2Department of Nephrology, Veterans Affairs Central California Health Care System, USA
*Corresponding author: Soe Naing, Associate Clinical Professor of Medicine, Director of Division of Endocrinology, Medical Director of Community Diabetes Care Center, University of California, San Francisco-Fresno Medical Education Program, Dept. of Internal Medicine, Suite A 2823 Fresno Street, Fresno, CA 93721, USA
Submission: April 04, 2018; Published: April 30, 2018
ISSN: 2578-0263Volume1 Issue3
Chronic kidney disease (CKD) is one of the most frequent microvascular complications of diabetes. Approximately 40% of adults with type 2 diabetes mellitus (T2DM) have CKD and about 50% of end-stage renal disease (ESRD) is caused by diabetes [1,2]. The hypoglycemia risk is increased in patients with advanced CKD (CKD stages 4 & 5) since clearance of insulin and of some of the non-insulin antihyperglycemic agents is reduced and there is an impaired renal gluconeogenesis with reduced kidney mass [3,4].
Keywords: Chronic kidney disease; Antihyperglycemic agents; Diabetes mellitus