Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, China
*Corresponding author: Guanghua Luo, Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and Treatment Associated with High Technology Research, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
Submission: February 26, 2018;; Published: March 05, 2018
ISSN: 2578-0263Volume1 Issue3
Apolipo protein A-V (APOA5) gene located on human 11q23 is an important determinant of plasma triglyceride levels . Obese children with hyperinsulinemia had higher triglyceride (TG) level and lower APOA5 level than those without hyperinsulinemia and serum APOA5was correlated negatively with TG level .Single nucleotide polymorphisms (SNPs) of APOA5 were found to be significantly associated with plasma/serum TG levels in children [3- 7]. SNP3 (ss3199915, now merged into rs662799) of APOA5gene was found to play an important role in the variation of serum TG levels. The serum TG levels of the subjects with C allele were significantly higher than those of the subjects with the T/T genotype.