Interventions in Obesity & Diabetes

Apolipoprotein A-V Genetic Variants in Obese Children

  • Open or Close Guanghua Luo*

    Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, China

    *Corresponding author: Guanghua Luo, Comprehensive Laboratory, Changzhou Key Lab of Individualized Diagnosis and Treatment Associated with High Technology Research, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China

Submission: February 26, 2018;; Published: March 05, 2018

DOI: 10.31031/IOD.2018.01.000511

ISSN: 2578-0263
Volume1 Issue3


Apolipo protein A-V (APOA5) gene located on human 11q23 is an important determinant of plasma triglyceride levels [1]. Obese children with hyperinsulinemia had higher triglyceride (TG) level and lower APOA5 level than those without hyperinsulinemia and serum APOA5was correlated negatively with TG level [2].Single nucleotide polymorphisms (SNPs) of APOA5 were found to be significantly associated with plasma/serum TG levels in children [3- 7]. SNP3 (ss3199915, now merged into rs662799) of APOA5gene was found to play an important role in the variation of serum TG levels. The serum TG levels of the subjects with C allele were significantly higher than those of the subjects with the T/T genotype.

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