Abstract

Disseminated Intravascular Coagulation (DIC), the most catastrophic obstetric acute emergency, is characterized by an inappropriate activation of coagulation & fibrinolytic system triggered by conditions like abruptio placentae & amniotic fluid embolism (release of thromboplastin intravascularly) or by diffuse endothelial damage as a result of pre-eclampsia. Clinical manifestation of severe bleeding and damaged coagulation profile are hallmarks of diagnosis, although histopathological demonstration of fibrin deposits is the pathognomonic feature of DIC. Understanding the basic pathophysiology, tackling the underlying etiological factor and replacement of the lost blood and specific components cover the principles of management of this condition.

Keywords: DIC; FFP; Thromboplastin coagulation failure; Coagulopathy

Abbreviations

DIC: Disseminated Intravascular Coagulation; HELLP: Hemolysis Elevated Liver Enzymes and Low Platelets Syndrome; IUFD: Intrauterine Fetal Death; FDP: Fibrin Degradation Products; FFP: Fresh Frozen Plasma; ISTH: International Society for Thrombosis and Hemostasis; AFE: Amniotic Fluid Embolism