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Investigations in Gynecology Research & Womens Health

A Study on Contraceptive Action

  • Open or Close Nripendra S1*, Ritu S2, Surendra S1 and Puja1

    1Department of Pharmacy, VBS Purvanchal University, Jaunpur, India

    2Department of Pharmaceutics, RRS college of Pharmacy, Amethi, India

    *Corresponding author:Nripendra S, Department of Pharmacy, VBS Purvanchal University, Jaunpur, India

Submission: June 03, 2019;Published: June 12, 2019

DOI: 10.31031/IGRWH.2019.02.000550

ISSN: 2577-2015
Volume2 Issue5


Vaginal contraceptive products have been available for many years and usually contain the membrane surfactant nonoxynol-9 (N-9) as one of the main ingredients. However, the major drawback of using surfactants is their detergent-type cytotoxic effect on vaginal cells. Besides, N-9 is also known to inactivate lactobacilli leading to disturbance of the vaginal microflora, which in turn increase the chances of STI/HIV transmission. Neem seed oil proved to be spermicidal against rhesus monkey and human spermatozoa in-vitro. Hexane extract of neem seed was reported to be precursor for immune contraceptive guided fraction whereas lyophilized neem leaf extract which is hydrophilic in nature has shown spermicidal activity against human spermatozoa in vitro. This review article proposes hydrophilic lipid for the extraction of hydrophilic and hydrophobic constituents from neem leaf to give novel aqueous neem leaf extract (NANE) which involves no use of organic solvent or thermal application and have no side effects. It is interesting to note that use of herbal contraceptives generally did not lead to permanent sterility, since discontinuation of the treatment allowed a prompt return to normal fertility.

Keywords: Contraception; Spermicidal activity; Novel aqueous neem leaf extract (NANE)

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