Faiza Ahmed2*, Ishita Gupta1 and Syed Siddiqi2
1Department of Medicine, India
2Department of Gastroenterology, USA
*Corresponding author: Faiza Ahmed, Department of Gastroenterology, USA
Submission: March 03, 2020;Published: March 09, 2020
ISSN 2637-7632Volume4 Issue3
Sucralfate drug is well known for its miraculous effects on gastroduodenal mucosa and its therapeutic effects on peptic ulcer, but its mechanism of action is still a mystery. This drug administration of 3g daily for 4-6 weeks is an effective treatment on gastric bicarbonate secretion. Our observational study was focused on gastric bicarbonate secretion in 14 healthy smokers and 11 healthy age and sex-matched nonsmoker volunteers. The outcome of the study suggested that smokers produced low gastric bicarbonate secretions compared to non-smokers.
Keywords: Low gastric bicarbonate; Cigarette smokers; Nicotine use; Gastric bicarb; Gastric secretions
Cigarette smoking is associated with a plethora of gastrointestinal disorders such as Crohn’s disease, [1,2] peptic ulcers, and esophageal cancer [3] during their lifetime [4,5]. Cigarette smoking is a major risk factor for the development of peptic ulcers, delay in healing ulcers and an increase in the rate of recurrence [2]. The numerous known effects of smoking that could contribute to these include [4,6]:
The mucosa of the stomach is known to secrete bicarbonate and hydrochloric acid [7]. About 10-55% of that secreted acid is neutralized by the gastric bicarbonate [1,3]. To the best of our knowledge, there are very limited reports or findings documented on the effect of smoking on gastric bicarbonate secretion. We came across many studies which suggest that sucralfate stimulates the secretion of gastric bicarbonate in patients with duodenal ulcers [6-10]. We decided to carry out our own study to find out if this fact might be one of the reasons why the drug overcomes the antagonistic effect of cigarette smoking in patients with duodenal ulcers.
We observed the effect of cigarette smoke on gastric bicarbonate secretion in 14 healthy smokers and 11 healthy age and sex-matched non-smoker volunteers. The smokers were permitted to smoke as per their daily routine. We also asked them to smoke two cigarettes before the one-hour collection of gastric secretions in a fasting state. Next, the volunteers were advised to expectorate their saliva during the study. If for some reason the collection of saliva included any amount of bile, these were discarded, and the study was repeated for accurate results.
The bicarbonate secretion rate of the stomach was predicted with the aid of a two-component model:
The mean gastric bicarbonate secretion recorded during the study was 0.78 to 0.16mmol/h in smokers and 4.25 to 1.08mmol/h in non-smokers (p<0.01). The outcome of the study suggested that smokers produced low gastric bicarbonate secretions as compared to non-smokers. This fact explains why the adverse effect of smoking is detected in patients with duodenal ulcer. Similarly, the reported beneficial effect of sucralfate therapy in patients with duodenal ulcer who continue smoking [8], could be attributed to this mechanism. However, a larger and more extensive study is necessary to validate our investigation (Figure 1).
Figure 1: Diagram listing different gastrointestinal disorders caused by cigarette use.
© 2020 Faiza Ahmed. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.