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1Department of Internal medicine, Military Hospital of Gabes, Tunisia
2Sfax Faculty of Medicine, University of Sfax, Tunisia
*Corresponding author: Salem Bouomrani, Department of Internal medicine, Military Hospital of Gabes, Gabes 6000, Tunisia
Submission: June 26, 2020; Published: December 14, 2021
ISSN 2637-7632Volume6 Issue3
With an average prevalence in the general population at 4-15% and more than 20% in the elderly, Subclinical Hypothyroidism (SCH) is the most common thyroid dysfunction. The clinical and biological impact of SCH is sometimes atypical, unusual, and very challenging in current medical practice. Among these atypical manifestations of SCH, some publications have suspected a particularly promoting role in the genesis of biliary lithiasis. The purpose of this review is to clarify the relationship between this thyroid dysfunction and gallstones. The systematic review of the literature allows us to conclude that the association between biliary lithiasis and SCH is far from mere chance. Diminished bile secretion, decreased liver cholesterol metabolism, and reduced sphincter of Oddi relaxation are the mechanisms involved in the formation and accumulation of biliary stones in subjects with S CH. Thus systematic screening for SCH is highly recommended in any patient diagnosed with biliary lithiasis.
Keywords: Biliary lithiasis; Subclinical hypothyroidism; Common bile duct stone; Gallstone; Hypothyroidism
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