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Abstract
Gastroenterology Medicine & Research
Vitamin B12 Replacement Therapy After Gastrectomy
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Open or CloseYasushi Rino1*, Toru Aoyama1, Takanobu Yamada2, Yosuke Atsumi1, Hiroshi
Tamagawa1, Takashi Oshima2, Tsutomu Sato3 and Norio Yukawa1
1Department of Surgery, Yokohama City University, School of Medicine, Yokohama, 3-9, Fukuura, Kanazawa-ku, Yokohama city, 236-0004, Japan
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, 2-3-2, Nakao, Asahi-ku, Yokohama city, 241-8515, Japan
3Gastroenterological Center, Medical Center, Yokohama City, Yokohama, 4-57 Urafune, Minami-ku, Yokohama 232-0024 Japan
*Corresponding author:Yasushi Rino, Department of Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan
Submission: March 03, 2021; Published: March 15, 2021
ISSN 2637-7632Volume5 Issue4
Abstract
Vitamin B12 absorption has two mechanism that are passive and active one. The active mechanism, controlled gastric intrinsic factor, occurs through the ileum and is efficient for small oral dose of vitamin B12. After gastrectomy, there is little intrinsic factor. Especially, after total gastrectomy (TG), intrinsic factor is lost. Cumulative vitamin B12 deficiency rate was 100% for TG after surgery. Usually, intramuscular injection of vitamin B12 for vitamin B12 deficiency after gastrectomy is performed. Recently, oral vitamin B12 replacement was reported. 500μg vitamin B12 replacement orally is maybe effective and necessary.
Keywords: Vitamin B12; Replacement therapy; Total gastrectomy; Gastric cancer; Oral vitamin B12 replacement
Abbreviations: TG: Total Gastrectomy; DG: Distal Gastrectomy
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