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Gastroenterology Medicine & Research

Vitamin B12 Replacement Therapy After Gastrectomy

Submission: March 03, 2021; Published: March 15, 2021

DOI: 10.31031/GMR.2021.05.000620

ISSN 2637-7632
Volume5 Issue4


Vitamin B12 absorption has two mechanism that are passive and active one. The active mechanism, controlled gastric intrinsic factor, occurs through the ileum and is efficient for small oral dose of vitamin B12. After gastrectomy, there is little intrinsic factor. Especially, after total gastrectomy (TG), intrinsic factor is lost. Cumulative vitamin B12 deficiency rate was 100% for TG after surgery. Usually, intramuscular injection of vitamin B12 for vitamin B12 deficiency after gastrectomy is performed. Recently, oral vitamin B12 replacement was reported. 500μg vitamin B12 replacement orally is maybe effective and necessary.

Keywords: Vitamin B12; Replacement therapy; Total gastrectomy; Gastric cancer; Oral vitamin B12 replacement

Abbreviations: TG: Total Gastrectomy; DG: Distal Gastrectomy

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