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Abstract

Gastroenterology Medicine & Research

Diagnostic Problems of Occult HBV Infection

  • Open or CloseMorozov IA1*, Ilchenko L Yu1,2, Fedorov IG2,3 and Tkachenko PE4

    1Chumakov Federal Scientific Center for research and development of immune-and-biological products of Russian Academy of Sciences, Russia

    2Pirogov Russian National Research Medical University, Russia

    3State Clinical hospital named after VM Buyanov, Russia

    4Sechenov First Moscow State Medical University, Russia

    *Corresponding author:Morozov IA ,Chumakov Federal Scientific Center for research and development of immuneand- biological products of Russian Academy of Sciences, Russia

Submission: March 11, 2020; Published: March 18, 2020

DOI: 10.31031/GMR.2020.04.000594

ISSN 2637-7632
Volume4 Issue4

Abstract

In this report we present current data on prevalence, clinical significance and methods of diagnostics of occult hepatitis B (OHB). Mechanisms of occult hepatitis B formation are reviewed, among which the most important is co-infection with other hepatotropic viruses. Diagnostic significance of anti-HBcAg antibodies is shown. An algorithm of occult hepatitis B detection developed by the authors involves two stages: detection of viral markers in serum and liver tissue. Attention is drawn to the role of morphologic methods including histochemistry, immunohistochemistry and electron microscopy in verification of HBV infection and direct visualization of virions in cytoplasm of hepatocytes.

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