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Abstract

Global Journal of Endocrinological Metabolism

COVID-19 Cytokine Storm Biomarkers. Comorbidities and Outcomes in Hemodyalisis Patients

Submission: October 08, 2020 Published: November 18, 2020

DOI: 10.31031/GJEM.2021.03.000557

ISSN 2637-8019
Volume3 Issue2

Abstract

Markers of inflammation and thrombosis have been well documented in patients with Covid-19. In parallel to it muscle markers of heart muscle can occur concomitantly in the case of kidney injury. The aim of the study was to investigate associations of the markers in Covid-19 patients and find out the connections among them aswell as with their other parameters. A total of 536 seriously affected Covid-19 patients were admitted to a tertiary hospital from February to September 2020. Their mean age was 63,4 years, being 61 percent male and on hemodyalisis. Their clinical, anthropometric, laboratory values and therapies were the basis for the construction of a data bank with 16700 informations. Statistical analysis was performed on the R system, due to the large size of data and for the sake of correlations being done among all the measurements. Having Creatin Kinase as reference variable, in descending order, the associations were with MB Creatin Kinase, C Reactive Protein, Creatinine, D Dimer, Lactic Dehydrogenase, Diabetes, Body Mass Index, Fibrinogen and Hypertension. When the marked variable was Troponin associations were MB Creatin Kinase, Lactic Dehydrogenase, D Dimer, Creatin Kinase, Diabetes, Fibrinogen, Creatinine, Dyslipidemia, C Reactive Protein, Body Mass Index, Race, Hypertension and Statin use. Associations of muscle markers as Troponin and Creatin Kinase were found with all inflammation and thrombosis markers as well as factors such as Race, Diabetes, Hypertension, Dyslipidemia, Body Mass Index and Statins are interrelated in Covid-19 infection. The large spectrum of concomitant alterations caused by the same disease demonstrates that these factors are not altered independently but by one and the same infectious agent. Patients on dyalisis showed the same pattern of biomarkers as the overall of Covid-19 patients in the Intensive Care Unit.

Keywords:Covid-19; Cytokine storm biomarkers; Comorbidities; Hemodyalitics; Inflammation; Thrombosis; Intensive care; Diabetes; Hypertension

Abbreviations: BMI - Body Mass Index; CK - Creatin Kinase;CRP - C Reactive Protein; ICU - Intensive Care Unit; LD - Lactic Dehydrogenase; MBCK - MB Creatin Kinase

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