Abstract

At the end of 2019, a global pandemic appeared first in China concerning a viral infection which quickly spread around the world concerning a new mutant of the Coronavirus called COVID-19 with active inter human transmission mainly by hands and more intense than the influenza virus flu. The clinical features are polymorphic, it can range from mild asymptomatic or even pauci-symptomatic forms (anosmia, conjunctivitis) to multi-visceral disorders such as acute respiratory distress syndrome, cytokine storm syndrome, acute renal failure, myocarditis, hematological disorders (thrombocytopenia) which cause death in frail people (elderly, diabetic) and patients with compromised immune system. The pathophysiological mechanism implicated in severe forms is linked to the direct cyto-pathogenic effect of the virus. In addition, hypofertility has been reported in infected people and recovered from covid-19 this has been linked to an effect on ACE2 receptors then disturb local testicular immunity causing orchitis.
Currently, if everyone agrees on social distancing, a big controversy has been observed concerning the indications for antiviral medical therapy such as hydroxychloroquine proposed by the Chinese and approved by Professor RAOULT. The specialists are divided into two groups, some are in favor of this treatment in particular for the moderate forms to prevent respiratory distress and others against this therapeutic protocol being justified by the toxicity of these drugs and the lack of recession of their use in full viral infection. The aim of this paper is to try to establish an indication of this treatment for moderate forms mainly in men who risk a little documented gonadal insufficiency even after recovery from this infection.