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Global Journal of Endocrinological Metabolism

U-500 Insulin: An Effective Treatment for Patients with Type 2 Diabetes and Severe Insulin Resistance

  • Open or Close Nasser Mikhail*

    Department of Medicine, Endocrine Division, USA

    *Corresponding author: Nasser Mikhail, Department of Medicine, USA

Submission: February 20, 2019 Published: March 14, 2019

DOI: 10.31031/GJEM.2019.03.000552

ISSN 2637-8019
Volume3 Issue1


Human regular insulin 500 (U-500) is a form of concentrated insulin that allows injection of high insulin doses with 5 times less volume compared with regular insulin. This concentrated insulin is indicated in patients with type 2 diabetes who require more than 200 units of insulin per day. Insulin U-500 displays both prandial and basal actions, and therefore can be injected as monotherapy in a convenient twicedaily regimen. Available data, mainly retrospective, suggest that insulin U-500 is effective, associated with better adherence, and decreased injection pain compared with non-concentrated insulins. Its main limitations are hypoglycemia and weight gain, and possibility of dosing errors. Randomized trials are needed to compare long-term efficacy and safety of insulin U-500 with other forms of insulin regimens.

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