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Abstract

Global Journal of Endocrinological Metabolism

New Insights into Inflammation in Atherosclerosis

  • Open or Close Michael AB Naafs*

    Naafs International Health Consultancy, Europe

    *Corresponding author: Michael AB Naafs, Dutch Internist Endocrinologist, Health Consultant at Naafs International Health Consultancy, Rhodoslaan, Oldenzaal, The Netherlands

Submission: September 10, 2018; Published: September 19, 2018

DOI: 10.31031/GJEM.2018.02.000547

ISSN 2637-8019
Volume2 Issue4

Abstract

In this mini-review recent developments in the pathogenesis, pathophysiology, biomarkers and therapeutics in residual inflammation of atherosclerosis are discussed. New cellular pathways are discovered raise new interest in old therapeutics as colchicine and niacin. Biomarker studies call for more specific and sensitive markers. The recent CANTOS trial provided clinicians evidence that directly targeting inflammation by canakinumab is beneficial for the secondary prevention of cardiovascular disease. Whole genome and exome studies will lead to the discovery of new cellular pathways and treatments of residual atherosclerotic inflammation.

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