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Global Journal of Endocrinological Metabolism

The Serotonergic System in Diet, Obesity and Mental Health
  • Open or Close Lina Begdache1* and Jade Marhaba2

    1Department of Health and Wellness Studies, Binghamton University, USA

    2Upstate Medical School, State University of New York, USA

    *Corresponding author: Lina Begdache, Department of Health and Wellness Studies, Binghamton University, USA

Submission: March 20, 2018; Published: April 04, 2018

DOI: 10.31031/GJEM.2018.01.000521

ISSN 2637-8019
Volume1 Issue5


Mental health and obesity research seldom intersect despite that poor diet and serotonergic system disturbances are common in both etiologies. Many interplaying factors lead to a concomitant dysregulation of the feeding centers and the limbic emotional processing centers. Leptin resistance, poor diet and lifestyle, inflammation, and psychological stress Interwine to disrupt these functions. Despite that many neurotransmitters play a role in these processes; the serotonergic system appears to be at the heart of these disturbances. Therefore, shedding the light on these factors and their effect on the serotonergic system may support a comprehensive therapeutic approach. Another goal for this review was to evaluate the cellular and molecular derangements associated with feeding disturbances and mental health to better shed the light on the intricate factors leading to their development.

Keywords: Leptin; Serotonin; Diet; Exercise; Inflammation; Stress; Obesity; Anxiety; Depression

Abbreviations: BBB: Blood-Brain Barrier; IL: Interleukin; 5-HT: 5-Hydroxytryptamine; HPA: Hypothalamic Pituitary Adrenal; PVN: Paraventricular Nucleus of the Hypothalamus; Tph: Tryptophan Hydroxylase; KO: Knockout; CNS: Central Nervous System; GABAergic: Gamma Aminobutyricacid Ergic; LNAA: Large Neutral Amino Acids; EPA: Eicosapentaenoic Acid; DHA: Docosahexaenoic Acid; CV: Cardiovascular; NPY: Neuropeptide Y; AgRP: Agouti Related Protein; POMC: Proopiomelanocortin; CART: Cocaine and Amphetamine Regulated Transcript; NMDA: N-methyl-D-aspartate

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