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Abstract

Global Journal of Endocrinological Metabolism

The Link between Cytokine Gene Polymorphisms and Recurrent Miscarrage
  • Open or Close AL Azzawie HF*

    Department Department of Biotechnology, Baghdad University, Iraq

    *Corresponding author: AL Azzawie HF, Department Department of Biotechnology, Baghdad University, Iraq

Submission: August 28, 2017; Published: November 13, 2017

DOI: 10.31031/GJEM.2017.01.000508

ISSN 2637-8019
Volume1 Issue2

Abstract

Recurrent miscarriage (RM), defined as three or more consecutive pregnancy losses before 20 weeks of gestation, affects approximately 1-5% of pregnant women [1]. The etiology of RM is still unclear. Among the large number of miscarriage-related factors, are uterine structural defaults, defective ploidy control of the embryo, defective immunological dialog between the embryo (or the fetus) and the uterus sometimes in relation with immunological disorders (such as autoimmune diseases), thrombophilia, and free radical metabolism imbalance [2]. Numerous studies attempted to correlate variants of genes supposed to be intervening in the different facets of the early maternal–fetal or maternal embryonic dialog, and eventually modify the outcome of fertilization, leading to success or failure of post implantation’ development.

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