Department of Oral medicine and Oral oncology, India
*Corresponding author: Shrihari TG, Department of Oral Medicine and Oral oncology, India
Submission: July 29, 2020;Published: October 09, 2020
ISSN 2578-0093Volume6 Issue2
Betaendorphin is an abundant endorphin, more potent than morphine. It has got analgesic, anti-inflammatory, immunestimulatory, and stress buster activity. Betaendorphin can be used in preventive, therapeutic, health promotive and palliative management of various diseases without adverse effects and inexpensive.
Keywords: NF-KB; STAT-3; HPA-AXIS
Beta-endorphin is an abundant endorphin, more potent than morphine, synthesized and stored in the anterior pituitary gland; it is a precursor of POMC (Proopiomelanocortin). Endorphins are produced during yoga, pranayama, intense physical exercise creates a psychological relaxed state known as ‘Runner’s high’, Love, tender, care, acupuncture, music therapy, dancing, singing, mindful meditation, sex, sympathy, empathy in caring the patient [1-4]. Beta-endorphin receptors are situated on the immune cells and nervous system. Beta-endorphin binds with μ receptors situated on the peripheral nerves results in inhibition of substance P, a neurotransmitter of pain and inflammation. Beta-endorphin binds with μ receptors situated on the central nervous system results in inhibition of GABA inhibitory neurotransmitter, produce dopamine neurotransmitter involved in analgesic activity, tranquility of mind (Stress buster activity), cognitive development, self-reward, euphoria, and addiction.
In an inflammatory state, binding of beta-endorphin to the μ receptors situated on the peripheral nerves results in inhibition of substance p, a neurotransmitter of pain and inflammation, produce anti-inflammatory cytokines such as IL-10, IFN-γ to reduce inflammation. Beta-endorphin receptors situated on the most innate and adaptive immune cells. Binding of beta-endorphin to the μ receptors situated on the innate and adaptive immune cells such as neutrophils, macrophages, natural killer cells, dendritic cells, mast cells, T cells, and B cells results in inhibition of IL-1β,IL-6,TNF-α pro-inflammatory cytokines, which inhibit the activation of NF-KB a key transcription factor involved in chronic inflammation, tissue damage and activation of innate and adaptive immune cells (immune stimulatory activity) results in release of IFN-γ, opsonin, granzyme-B, and antibodies results in anti-inflammatory activity, anti-viral activity, anti-bacterial activity, anti-tumor activity [1-8]. All these mechanisms of actions of beta-endorphin helpful for future management of diseases such as heart diseases, Alzheimer’s disease, cancer, diabetes mellitus, infectious diseases, and aging without adverse effects and economical. Thorough understanding of beta-endorphin, mechanisms of actions, dose dependent duration of action needed for application in management of diseases.
© 2020 Shrihari TG. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.