Abstract

Basic research in the area of indirect research promotes public politics and preventive programs to help health care, using as a main tool the thorough investigation of pathological processes of different clinical conditions. In osteoarthritis, the rates of medical appointments and leave from work can be minimized with an understanding of all the mechanisms involved in the disease. An osteoarthritis presents a sequence of morphological changes characterized by the loss of the normal configuration of the extracellular cartilage matrix, crackling on movement, bone deformities, formation of osteophytes and increased synovial fluid. Pain is not the first clinical sign of the disease, mainly due to the a neural and avascular resources of the articular cartilage, but it is consensual in the literature that since the beginning of the disease existing in the inflammatory process in the joints.