Abstract

We treat Parkinson’s disease with high dose thiamine in addition to the classic therapy since 2012. On this topic, we published three studies carried out with Italian patients [1-3]. The treatment consisted in performing 2-3 intramuscular injections of 100mg of thiamine per week. The highest dosage was reserved to patients whose disease severity was the greater, long past onset, and patients whose weight was more than 90kg. We also treated patients on anticoagulants. In this case, the thiamine was administrated orally (tablets). We noticed that in order to obtain comparable results of the intramuscular therapy with the oral therapy we needed to administrate a dose of thiamine 140 times when treated with tablets or capsules (personal data, not published). In other words, in order to obtain the same clinical effect of 1 intramuscular injection of 100mg of thiamine once a week, it was necessary to administrate 14 grams of thiamine orally per week, or 2 grams per day. This dosage, when appropriate for the patient, has always been well tolerated and we did not observe collateral effects.