Crimson Publishers Publish With Us Reprints e-Books Video articles


Gerontology & Geriatrics Studies

Co morbidity and Neuroimaging in Alzheimer’s Disease

Submission: November 11, 2017; Published: June 15, 2018

DOI: 10.31031/GGS.2018.03.000567

ISSN: 2578-0093
Volume3 Issue4


Multiple medical co morbid conditions are common in older adults. Patients with dementia and high comorbidity are characterized by the most compromised health status. This study aims to assess the correlation of Magnetic Resonance Imaging (MRI) data and medical co morbidity in patients with Alzheimer’s disease (AD). The study is based on data collected from the European Study Innomed. Clinical and MRI data were collected from six European sites. Patients had to meet the ADRDA/NINCDS and DSM -IV criteria, and the MMSE score was ≤23. A total of 61 AD patients’ data, were analyzed. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) was used to calculate the co morbidity burden. MRI volume of 14-brain regions of interest, mostly mentioned as affected by AD in literature, were analyzed. The impact of co morbidity, on the volume of the selected MRI areas of the 61 patients with AD, was assessed via Spearman correlation coefficient. The correlation of CIRS-G with the volume of the brain areas of interest showed that there was no statistically significant correlation. Co morbidities, based on our results, do not largely influence the brain volume of the investigated areas, additionally to the neurodegenerative disease. Age and gender are confounders regarding the brain atrophy in AD.

Get access to the full text of this article