1Neurology Clinic, General Hospital of Thessaloniki Agios Pavlos, Greece
23rd Department of Neurology, Aristotle University of Thessaloniki, Greece
3Department of Gerontology and Geriatrics, University of Perugia, Italy
4Department of Neurology, University of Toulouse, France
5Department of Neurology, University of Kuopio, Finland
6Department of Old Age, Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland
7MRC Centre for Neurodegeneration Research, Institute of Psychiatry King’s College London, UK
8Department of Psychiatry, University of Oxford, UK
*Corresponding author: Tsolaki Anthoula, Neurology Clinic, General Hospital of Thessaloniki, Ellis Alexiou 19, 55535 Thessaloniki, Greece
Submission: November 11, 2017; Published: June 15, 2018
ISSN: 2578-0093Volume3 Issue4
Multiple medical co morbid conditions are common in older adults. Patients with dementia and high comorbidity are characterized by the most compromised health status. This study aims to assess the correlation of Magnetic Resonance Imaging (MRI) data and medical co morbidity in patients with Alzheimer’s disease (AD). The study is based on data collected from the European Study Innomed. Clinical and MRI data were collected from six European sites. Patients had to meet the ADRDA/NINCDS and DSM -IV criteria, and the MMSE score was ≤23. A total of 61 AD patients’ data, were analyzed. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) was used to calculate the co morbidity burden. MRI volume of 14-brain regions of interest, mostly mentioned as affected by AD in literature, were analyzed. The impact of co morbidity, on the volume of the selected MRI areas of the 61 patients with AD, was assessed via Spearman correlation coefficient. The correlation of CIRS-G with the volume of the brain areas of interest showed that there was no statistically significant correlation. Co morbidities, based on our results, do not largely influence the brain volume of the investigated areas, additionally to the neurodegenerative disease. Age and gender are confounders regarding the brain atrophy in AD.