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Forensic Science & Addiction Research

Forensic Application of DNA Methylation in Age- Prediction

  • Open or CloseAlisraa Althagafi1, Mohammad Algahtani2 and Abdurahman Theyab3*

    1Department of Laboratory Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia

    2Department of Laboratory Medicine, The Comprehensive Specialized Clinics of The Security Forces, Jeddah, Saudi Arabia

    3Department of Laboratory Medicine, Security Forces Hospital, Makkah, Saudi Arabia

    *Corresponding author: Abdurahman Theyab, Department of Laboratory Medicine, Security Forces Hospital, Makkah, Saudi Arabia

Submission: September 03, 2019;Published: September 12, 2019

DOI: 10.31031/FSAR.2018.04.000612

ISSN: 2578-0042
Volume5 Issue2


Advances in Epigenetics suggested that DNA methylation profiling, plays an important role in various biological process such as silencing, maintaining or expression of genomic stability. DNA methylation is the most comprehensively studied epigenetic mark, and it involves the addition of a methyl group to the 5′ cytosine of CG dinucleotide, referred to as CpGs. DNA methylation is related to gene regulation and cell differentiation by affecting transcription factor binding sites, insulator components, and chromosome morphology. Recent advances suggested that DNA methylation markers not only can provide information about tissue of origin of evidence sample, but also can rely information about the age and lifestyle or environmental exposure of an individual, for an unknown suspect. In this review, we will be discussing age-associated DNA methylation in various tissues, blood and semen and the applicability of the DNA methylation-based age prediction method to the forensic investigations.

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