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1Department of Laboratory Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
2Department of Laboratory Medicine, The Comprehensive Specialized Clinics of The Security Forces, Jeddah, Saudi Arabia
3Department of Laboratory Medicine, Security Forces Hospital, Makkah, Saudi Arabia
*Corresponding author: Abdurahman Theyab, Department of Laboratory Medicine, Security Forces Hospital, Makkah, Saudi Arabia
Submission: September 03, 2019;Published: September 12, 2019
ISSN: 2578-0042Volume5 Issue2
Advances in Epigenetics suggested that DNA methylation profiling, plays an important role in various biological process such as silencing, maintaining or expression of genomic stability. DNA methylation is the most comprehensively studied epigenetic mark, and it involves the addition of a methyl group to the 5′ cytosine of CG dinucleotide, referred to as CpGs. DNA methylation is related to gene regulation and cell differentiation by affecting transcription factor binding sites, insulator components, and chromosome morphology. Recent advances suggested that DNA methylation markers not only can provide information about tissue of origin of evidence sample, but also can rely information about the age and lifestyle or environmental exposure of an individual, for an unknown suspect. In this review, we will be discussing age-associated DNA methylation in various tissues, blood and semen and the applicability of the DNA methylation-based age prediction method to the forensic investigations.
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
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