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Abstract

Experimental Techniques in Urology & Nephrology

Protective Effects of Antioxidants on Kidney Disease

  • Open or Close Ghahari L1 and Safari M2*

    1 Aja University of Medical Sciences, Iran

    2 Department of Anatomy, Research Center of Nervous System Stem Cells, Semnan University of Medical Sciences, Iran

    *Corresponding author: Manouchehr Safari, Research Center of Nervous System Stem Cells, Department of Anatomy, Semnan, Iran

Submission: December 12, 2018; Published: January 09, 2019

DOI: 10.31031/ETUN.2019.02.000543

ISSN: 2578-0395
Volume2 Issue4

Abstract

Oxidative stress is an imbalance between the amount produced and the removal of oxidants produced. In other words, the increase in reactive oxygen species (ROS) or reactive nitrogen species (RNS) and/or the reduction of the antioxidant/intrinsic/extrinsic is the main cause of this problem [1]. This is one of the most important causes of acute and chronic kidney disease [2]. Increasing the accumulation of free radicals within the kidney resulting from the malfunctioning of the antioxidant defense will ultimately lead to acute renal tubule necrosis, impaired function, and ultimately reduced glomerular filtration (GFR) [3]. The important factors of ROS molecules are hypochlorous acid, superoxide anion, hydrogen peroxide and hydroxyl radical. Because ROS molecules are very active, they quickly destroy molecules such as fats, DNA and proteins [4]. The factors that cause elevation of ROS and its products in the kidney cells are inflammatory cytokines, angiotensin II, mechanical pressure, hyperglycemia, protein kinase C (PKC), free fatty acids, TGF-beta1 and NADPH oxidases enzymes (NOXs). NADPH oxidases (NOXs) are enzymes that produce ROS. The NOX family contains seven subgroups (NOX1- 5 and DUOX 1 and 2) [5].

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