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Abstract

Examines in Physical Medicine & Rehabilitation

Fermented Inonotus Obliquus Inhabit Proliferation of Hepatocellular Carcinoma HepG2 Cells through inducing Apoptosis and G0/G1 Cell Cycle Arrest

  • Open or Close Rui Hou1 and Weiping Ma2*

    1 Department of Ultrasonic Diagnosis, China

    2 School of Medicine and pharmacology, China

    *Corresponding author:Weiping Ma, School of Medicine and Pharmacology, China

Submission: January 21, 2019; Published: March 11, 2019

DOI: 10.31031/EPMR.2019.02.000536

ISSN: 2637-7934
Volume2 Issue3

Abstract

Inonotus Obliquus have many pharmacological effects. The aim of this study was to evaluate the effect of fermented Inonotus Obliquus (FIO) on hepatocellular carcinoma HepG-2 cells and preliminarily study on possible mechanism. The contents of polysaccharides, terpenoids and polyphenols in unfermented Inonotus Obliquus (UIO) and FIO were determined and he effect of on hepatocellular carcinoma HepG-2 cells was determined. Compared with UIO, the contents of polysaccharides, polyphenols and terpenoids of FIO were significantly increased (P<0.01). FIO significantly inhibited the proliferation of HepG-2 cells and induced HepG-2 apoptosis. The mechanism may be through increased the ratio of G0/G1 phase was (P<0.05) and increase the expression of Cytochrome C and Caspase-3 apoptotic proteins.

Keywords: Fermented Inonotus Obliquus; Apoptosis; Cell cycle arrest

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