1 Department of Ultrasonic Diagnosis, China
2 School of Medicine and pharmacology, China
*Corresponding author:Weiping Ma, School of Medicine and Pharmacology, China
Submission: January 21, 2019; Published: March 11, 2019
ISSN: 2637-7934Volume2 Issue3
Inonotus Obliquus have many pharmacological effects. The aim of this study was to evaluate the effect of fermented Inonotus Obliquus (FIO) on hepatocellular carcinoma HepG-2 cells and preliminarily study on possible mechanism. The contents of polysaccharides, terpenoids and polyphenols in unfermented Inonotus Obliquus (UIO) and FIO were determined and he effect of on hepatocellular carcinoma HepG-2 cells was determined. Compared with UIO, the contents of polysaccharides, polyphenols and terpenoids of FIO were significantly increased (P<0.01). FIO significantly inhibited the proliferation of HepG-2 cells and induced HepG-2 apoptosis. The mechanism may be through increased the ratio of G0/G1 phase was (P<0.05) and increase the expression of Cytochrome C and Caspase-3 apoptotic proteins.
Keywords: Fermented Inonotus Obliquus; Apoptosis; Cell cycle arrest