Abstract

Cigarette smoking is a poor factor for multiple organs and systems in our body, which can promote the occurrence of cancer and increase the risk of cardiovascular accidents. Meanwhile, smoking also plays an important role in the development of Chronic Kidney Disease (CKD). Smoking promotes the development of renal fibrosis through the following mechanisms: Endothelial cell dysfunction, oxidative stress, activation of growth factors, tubular atrophy, insulin resistance, Advanced Glycation End Products (AGEPs) formation and impaired lipoprotein metabolism. And, smoking is associated with increased risk of proteinuria than non-smoking. Thus, smoking is a poor independent risk factor for our body, which should be cessation and take more appreciate.

Keywords: Smoking; Chronic kidney disease; Renal fibrosis