Determinations in Nanomedicine & Nanotechnology

The Technology of Obtaining Nanomedicines from Deer Antlers Development

Sevil Mehraliyeva¹*, Elmar Babayev², Betul Ceviz Sakar³ and Zeyneb Orhan³

¹Department of pharmaceutical technology and management, Azerbaijan

²Institute of Zoology of the Azerbaijan National Academy of Sciences, Azerbaijan

³Eastern Anatolia High Technologies Application and Research Center, Turkey

*Corresponding author: Sevil Mehraliyeva, Department of Pharmaceutical Technology and Management, Azerbaijan

Submission: October 26, 2022;Published: November 04, 2022

DOI: 10.31031/DNN.2022.03.000553

ISSN: 2832-4439
Volume3 Issue1

One of the urgent issues facing nanotechnology is to create new drug forms by covering the surface of unstable drugs with polymers of natural or synthetic origin, as well as ensuring their long-term effect. Unstable substances include amino acids, enzymes, hormones, vitamins, etc. it can be noted that these are also collected in the maximum amount in deer antlers [1-4]. Since 8 out of 11 climate zones are in Azerbaijan, Altai deer are well adapted to the climatic conditions here. Maralls have a sufficient raw material base in Azerbaijan. Thus, reindeer husbandry has been established in Altyağac, Shamakhi, PirAllahi regions. In addition to countries like Japan, Vietnam, China, Korea, and Russia, Pant baths have been widely used in Azerbaijan since 2015. This eliminates chronic fatigue syndrome and improves the emotional state of a person. It also increases the intensity of metabolism and metabolic processes in the body and accelerates microcirculation in the vessels. In addition, diseases of the urogenital system, gastrointestinal system, bronchial asthma, osteochondrosis and a number of skin diseases are treated [5-7].

In the course of research, it was determined that medicinal preparations and cosmetology products made from deer antlers have a number of shortcomings. This is due to their short useful life, adverse effects in arterial hypertension, atherosclerosis, active form of tuberculosis, severe kidney diseases, diarrhea, brain trauma and epilepsy, and at the same time, their bio absorption by the body is low. It is for the purpose of ensuring more active absorption and effect of medicinal substances that therapeutic systems are developed, which increase absorption by 8-10 times. Such drug delivery systems ensure the delivery of the active substance to the damaged area, i.e. the target cell, preventing damage to healthy cells during treatment [8,9]. The purpose of the study. Taking into account the above, we have prepared extracts from deer antlers with a special technological method and considered it appropriate to create nano capsules by covering their surface with polymers such as carrageenan and tragacanth.

Materials and methods of research. Deer antlers presented from the Altyagac deer farm of Azerbaijan were crushed and extracted. The research work was carried out in the laboratory of the Department of Pharmaceutical Technology of the Azerbaijan Medical University and DAYTAM (East Anatolian Yüksek Teknoloji Uygulama ve Araştırma Merkezi), which operates under Atatürk University in Turkey. Non-ossified deer horns were used for the research. SEM analysis of nano capsules prepared from deer antlers was carried out on a Zeiss Sigma 300 device. TEM analysis of nano capsules was performed on a Hitachi HT7700 device. Nano capsules from deer antlers, distilled water, an ultrasonic water bath, and a carbon-coated grill were used for the research [10].

SEM of nano capsules prepared with carrageenan as a result of the analyzes conducted at DAYTAM was determined to be 118.3- 243.6nm in TEM, 10-248nm in TEM, and 33.15-224.1nm in SEM and 15-218nm in TEM of nano capsules prepared with gum arabic. Thus, the nano capsules prepared with gum arabic were proven to be more intense and more stable, which in the future will allow the nano capsules to be transported to the pathological site in the treatment of relevant diseases (oncology, infertility, osteoarthritis, cardiovascular, nervous system), the binding of the drug to the relevant receptors located in the target cells, the rate of release of the drug and will allow a high pharmacotherapeutic effect.

1. Zang Z, Tang H, Tuo Y, Wei JX, Su Yun J, et al. (2016) Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice. The Asian Journal of Andrology 18(4): 613-619.
2. Mehralıyeva SC (2022) Nanotechnologies in the field of development of medicines on the basis of natural raw materials. Karabakh III İnternational congress of applied sciences Year of Shusha-2022, Azerbaijan: pp.158-164.
3. Zemtsova NP, Turetkova VF, Makarova OG (2016) Determination of amino acids in deer antlers: Validation of the methodology. Pharmacy Moscow 4: 38-41.
4. Delcea M, Yashchenok A, Videnova K , Kreft O, Möhwald H (2010 ) Multicompartmental micro-and nanocapsules: Hierarchy and applications in biosciences. Macromolecular Bioscience 10(5): 465-474.
5. Mehraliyeva S (2022) Claim document for the invention No. a 2022 0046. Method of preparation of nanocapsule, Azerbaijan.
6. Sevil Mehraliyeva, Elmar Babayev (2022) Preparation of nanoemulsion from deer antlers (Cervus elaphus sibiricus) fed in Azerbaijan and assessment of some quality indicators. Scientific Collection InterConf (105): with the Proceedings of the 5^th International Scientific and Practical Conference. Current Issues and Prospects for The Development of Scientific Research, France: pp. 267-275.
7. Mehraliyeva Sevil (2022) Analysis of nanocapsules prepared from deer antlers. Current problems of medicine.
8. Mehralıyeva SC, Musayeva SE, Ceviz Şakar B, Orhan Z (2022) Morphological analysis of nanocapsules prepared on the basis of extract from deer antlers. Journal of Medicine and Science 27: 45-51.
9. Truc L, Thuy T, Huyen TT, Thuan D, Nguyen T (2022) Anti-Aging effects of a serum based on coconut oil combined with deer antler stem cell extract on a mouse model of skin aging. Cells 11(4): 597.
10. Mehmet Ateş (2018) Measurement and inspection techniques of nanoparticles. Turkish Journal of Scientific Reviews 11(1): 63-69.