Abstract

Since the innovation of nanomedicine decades ago, significant advances have been made, especially with cancer as an objective. Nanoparticles in cancer remediation intends to cover different important aspects in this field including development of nanocarrier, delivery of gene, intrinsically active nanoparticles (NPs), microenvironment of tumor, toxicity, and immunology. The mostly applied biocompatible nanocarriers in clinical experiments are lipid, polymer, and protein-based materials. Polymeric micelles are a common type of nanocarriers for drug delivery due to their multifunctionality, controllable release, and biocompatibility. Doxorubicin as a model drug was successfully loaded into the micelles and presented a complete and rapid drug release at pH=5.0. The drug loaded NPs had high anti-tumor activity to kill the cancer cells but minimum toxicity to ordinary cells.