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Abstract
COJ Technical & Scientific Research
NADP Stimulates DNA Reparation after Thermodynamic Stress in Cardiomyocytes of Aging MDX Mice
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Open or Close E Mikhailova1,3*, I Vezhenkova1, D Firsanov1, E Kaminskaya1, V Kazakov1, A Gudkova2 and V Mikhailov1
1 Institute of Cytology, Russian Academy of Sciences, Russia
2 Northwestern Federal Medical Research Center, V.A. Almazov of the Ministry of Health of the Russian Federation, Russia
3 St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, Russia
*Corresponding author: E Mikhailova, Ministry of Health of the Russian Federation, 194156, Saint-Petersburg, Thikhoretsky av, Russia
Submission: November 01, 2018; Published: November 16, 2018
Abstract
Using thermodynamic stress we aim to analyze the possibility of regulating the DNA double strand (DSBs) formation in heart tissue of aging mdx mice by intraperitoneal injections of NADP+ which is shown to mediate key regulators of oxygen stress and cell death.
Keywords: Heart; Cardiomyocytes; Dynamic Stress; DNA Reparation; MDX Mice
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