Crimson Publishers Publish With Us Reprints e-Books Video articles

Full Text

COJ Nursing & Healthcare

The Compromised, Pre-Diseased or Post-Diseased Terrain, Malaria and Germ Terrain Dualism

Mister Seun Ayoade*

BSc (Hons) Physiology, Nigeria

*Corresponding author: SMister Seun Ayoade, BSc (Hons) Physiology, PO. Box 22325, Oyo State, Nigeria

Submission: July 02, 2018;Published: November 02, 2018

DOI: 10.31031/COJNH.2018.04.000585

ISSN: 2577-2007
Volume4 Issue2


The Germ-Terrain duality theory of disease states that the aetiology of certain diseases/diseased states is better explained as a complex interplay between germs and the inherent anatomical/ physiological integrity of the body cells [1]. It argues that the aetiology of certain diseases is not fully explained merely by the presence of germs (Germ Theory) or by a mere loss of cellular integrity (Terrain Theory) [2-6]. As a result, the prevention and treatment of such diseases should focus not just on fighting germs but on maintaining/ restoring the anatomical/physiological cellular integrity [7-11]. The Germ-Terrain duality theory is a harmonization of the current Germ Theory (popularized by Louis Pasteur) and the hitherto discarded Terrain Theory (popularized by Pierre Bechamp) [11-14].

If an unhealthy/pre-diseased person is infected with malaria, what happens? What is the effect of malaria in an individual whose anatomical/physiological terrain (integrity wise) has been compromised prior to (or after) infection? (Table 1).

Table 1:The above show terrain has a role to play in the aetiology of malaria.


  1. Ayoade S (2017) Etiology, epidemiology and therapeutic history of malaria validate germ-Terrain duality; postulates thereof. J Mol Genet Med 11: 261.
  2. Ayoade S (2017) Thalassemias validate germ terrain duality of Malaria. Health Sci J 11: 3.
  3. (2011) Association of ABO blood group and plasmodium falciparum malaria in dore bafeno area, Southern Ethiopia tewodros zerihun,1 abraham degarege, 2 and Berhanu Erko. Asian Pac J Trop Biomed 1(4): 289-294.
  4. Alexandra RJ, Ian GH, Mahamadou AT, Anne MD, Kirsten EL, et al. (2007) Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced resetting. Proc Natl Acad Sci U S A 104 (44): 17471-17476.
  5. Francisco JA, Alexandra RJ, Herbert D, Thomas NW (2010) Blood groups and malaria: Fresh insights into pathogenesis and identification of targets for intervention. Curr Opin Hematol 16(6): 480-487.
  6. Wahlgren M (2017) How blood group O protects against malaria. Nature Medicine.
  7. Malaria world Pierre Lutgen Does diabetes have antimalarial properties.
  8. Centre for disease control dispatch type 2 Diabetes Mellitus and Increased Risk for Malaria Infection I Danquah FP Mockenhaupt) Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, West Africa.
  9. Gopal RN (2015) Malaria: people with blood group A more vulnerable to severe disease. The Hindu March.
  10. Negative link between malaria resistance and cancer metastasis. Xuan Pham. Labroots.
  11. Anuraj HS (2000) Nutritional modulation of malaria morbidity and mortality. The Journal of Infectious Diseases 182(Suppl 1): S37-S53.
  12. WHO. Malaria In pregnant Women.
  13. American Heart Association News. Scientists propose a malaria-high blood pressure link By American Heart Association News.
  14. Malaria and HIV AIDS.

© 2018 Mister Seun Ayoade. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.