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Abstract

COJ Nursing & Healthcare

Evaluation of Enzymes Involved in the Production of Endogenous Reactive Oxygen Species and Role of Long-term Oxidative Stress in Pathobiology of Atherosclerosis with Common Oxidative Stress Markers

Submission: March 27, 2020; Published: January 28, 2021

DOI: 10.31031/COJNH.2021.07.000652

ISSN: 2577-2007
Volume7 Issue1

Abstract

Free radicals are molecules with an unpaired electron; thus, they are highly reactive. The human body deals with the pathological effects of free radicals by utilizing antioxidant system. The concentration and location of ROS are the main determinants of their effect. Although there are several sources of vascular free radicals, the enzyme NADPH oxidase is emerging as a strong candidate for the excessive ROS production. A multitude of studies provide evidence that an uncontrolled production of ROS is involved in the development and progression of cardiovascular disease like atherosclerosis. Atherosclerosis is characterized by the formation of intimal plaques. Monitoring and rapid detection of oxidative stress markers is necessary to combat the spread of various diseases.

Keywords: Free radicals; ROS; Antioxidant; Atherosclerosis; Oxidative stress markers

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