¹Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

²State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

³State Key Laboratory of Respiratory Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Medical University, Guangzhou, China

⁴Internal medicine department, Jiangxi Yihuang Hospital of Traditional Chinese, Yihuang, China

⁵Guangdong Sanmai Biotechnology Co., Ltd, Guangzhou, China

^#Contributed equally to this article

*Corresponding author: Zhenwei Liu, Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University,Guangzhou, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University,Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Medical University, Guangzhou, China Dehui Chen, Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.