Abstract

Stealth adaptation is a virus immune evasion/escape mechanism that comprises the deletion or mutation of the viral genes, which code for components targeted by cellular immunity. It can also require the incorporation of additional genetic sequences to regain the capacity for replication and transmission. Stealth adapted viruses typically cause noninflammatory infections, which are particularly symptomatic when they involve the brain. Stealth adaptation has occurred with cytomegalovirus contaminants of polio vaccines produced in kidney cell cultures of rhesus and African green monkeys. Two aspects of the current Covid-19 vaccines are conducive to the formation of stealth adapted SARS-CoV-2 coronaviruses. These are the relative ineffectiveness of intramuscular injections in stimulating fully effective respiratory mucosal immunity, and the inclusion of only a single virus component as the immunogen, namely the spike protein. Stealth adapted coronaviruses will have the potential to cause chronic, non-inflammatory brain illnesses similar to those being caused by stealth adapted monkey cytomegaloviruses. These include the chronic fatigue syndrome (CFS) and autism. The long Covid syndrome has many features in common with CFS and the affected patients need to be evaluated for stealth adapted virus infections. With regards to potential therapy, the body has a non-immunological anti-virus defense mechanism that is mediated by the alternative cellular energy (ACE) pathway. Enhancing the ACE pathway, especially in those susceptible to severe Covid-19 illness and in those who are experiencing the long Covid syndrome, is preferable to having to repeatedly vaccinate mankind against evolving variants of the SARS-CoV-2 virus. Furthermore, immunization is not indicated in those who are already infected With the stealth adapted coronavirus. Optimizing ACE pathway-based therapies will also have benefits in treating other stealth adapted virus brain diseases including CFS and autism.

Keywords: Stealth adapted viruses; SARS-CoV-2; Covid-19; Long COVID syndrome; Chronic fatigue syndrome; Polio vaccine

Abbreviations: ACE: Alternative Cellular Energy; CFS: Chronic Fatigue Syndrome; CTL: Cytotoxic T Lymphocyte