Abstract

Intestinal organoid models derived from farm animals have great potential to contribute to both agriculture and human health as a one health initiative, which recognize a cohesive relationship among farm animals, humans, and their shared environment. This is because the Three-Dimensional (3D) organoids maintain the self-organizing and self-renewing properties as well as the high structural and functional similarities to the originating donor tissues [1]. Intestinal organoids from farm animals could play an important role in investigations of the pathophysiology of enteropathogens that could lead to chronic wasting disease and low agricultural production or zoonotic diseases that poses significant threats to public health [2]. Here, we discuss the integration of intestinal organoid culture and gut-on-a-chip systems in farm animals to potentially overcome current limitations in in vitro studies in public health and food security as one health initiatives. We envision multidisciplinary work integrating intestinal organoid culture and microfluidic gut-on-a-chip technology can contribute to improving both human and farm animal health.

Keywords:Farm animals; Intestinal organoid; Gut-on-a-chip; One health; Public health

Abbreviations: 3D: Three-Dimensional; PEDV: Porcine Epidemic Diarrhea Virus; PDCoV: Porcine Deltacoronavirus; TGEV : Transmissible Gastroenteritis Virus