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Abstract
Approaches in Poultry, Dairy & Veterinary Sciences
Factors Affecting the Transfer of Leptin Through Blood-Brain Barrier (BBB). The Implication for Leptin Resistance
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Open or CloseDorota A Zięba*
Department of Animal Nutrition, and Biotechnology, and Fisheries; Laboratory of Biotechnology and Genomics, University of Agriculture in Krakow, Poland
*Corresponding author: Dorota A Zięba, Department of Animal Nutrition, and Biotechnology, and Fisheries; Laboratory of Biotechnology and Genomics, University of Agriculture in Krakow, 30-248 Krakow, Poland
Submission: September 24, 2019;Published: October 03, 2019
ISSN : 2576-9162Volume6 Issue4
Abstract
The base of the leptin resistance hypothesis promulgated several years ago consists of two tenets: the extinction of leptin-induced intracellular signaling downstream of leptin binding to the long form of neuronal receptor (LTRb) in the hypothalamus and impedance to leptin entry imposed at the blood-brain barrier (BBB). A recent comprehensive literature review [1] has led to the conclusion that central leptin insufficiency associated with the metabolic syndrome is due to reduced BBB leptin transport efficiency, and not just to leptin insensitivity in the hypothalamus.
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