Abstract

This review explores the immune response mechanisms and biological properties of T-cells and circulating hematopoietic stem and progenitor cells (HSPCs). T-cells are crucial components of adaptive immunity, possessing unique mechanisms for antigen recognition, activation, differentiation, and effector functions. They play a vital role in eliminating pathogens and maintaining immune homeostasis. Circulating HSPCs, found in the bone marrow and peripheral blood, exhibit self-renewal, multipotency, and mobilization capabilities. These properties enable HSPCs to generate various blood cell lineages, including T-cells, and contribute to immune system function. The interactions between T-cells and HSPCs are bidirectional, with both cell types influencing each other’s development and function. Understanding the interplay between T-cells and circulating HSPCs has significant clinical implications, including the development of immunotherapies and regenerative medicine applications. Harnessing the potential of T-cells and HSPCs holds promise for advancing treatments for immune-related diseases and improving patient outcomes. Further research in this field will undoubtedly contribute to our understanding of immune responses and pave the way for novel therapeutic approaches.

Keywords:Immune response mechanisms; T-cells; Hematopoietic stem and progenitor cells; multipotency; Mobilization capabilities