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Associative Journal of Health Sciences

Immune Response Mechanisms and Biological Properties of T-Cells and Circulating HSPCs: A Review

  • Open or CloseKovuri Umadevi1, Dola Sundeep2*, Ragala Jhansi3,4, R Nagarjuna Chary1 and P Meher Baba3

    1Department of Pathology, Government Medical College and Hospital, Telangana, India

    2Biomedical Research Laboratory, Indian Institute of Information Technology Design and Manufacturing, India

    3Department of Prosthodontics and Crown & Bridge, St. Joseph Dental College and Hospital, India

    4Department of Prosthodontics, Vishnu Dental College, India

    *Corresponding author:Dola Sundeep, Biomedical Research Laboratory, Indian Institute of Information Technology Design and Manufacturing, Jagannathagattu Hill, Kurnool-518008, Andhra Pradesh, India

Submission: June 12, 2023;Published: July 28, 2023


This review explores the immune response mechanisms and biological properties of T-cells and circulating hematopoietic stem and progenitor cells (HSPCs). T-cells are crucial components of adaptive immunity, possessing unique mechanisms for antigen recognition, activation, differentiation, and effector functions. They play a vital role in eliminating pathogens and maintaining immune homeostasis. Circulating HSPCs, found in the bone marrow and peripheral blood, exhibit self-renewal, multipotency, and mobilization capabilities. These properties enable HSPCs to generate various blood cell lineages, including T-cells, and contribute to immune system function. The interactions between T-cells and HSPCs are bidirectional, with both cell types influencing each other’s development and function. Understanding the interplay between T-cells and circulating HSPCs has significant clinical implications, including the development of immunotherapies and regenerative medicine applications. Harnessing the potential of T-cells and HSPCs holds promise for advancing treatments for immune-related diseases and improving patient outcomes. Further research in this field will undoubtedly contribute to our understanding of immune responses and pave the way for novel therapeutic approaches.

Keywords:Immune response mechanisms; T-cells; Hematopoietic stem and progenitor cells; multipotency; Mobilization capabilities

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