Crimson Publishers Publish With Us Reprints e-Books Video articles


Advances in Complementary & Alternative medicine

Perspectives of Complement System in Inflammatory Diseases

  • Open or Close Lalit M Srivastava*

    Department of Biochemistry and Lab Medicine, Sir Ganga Ram Kolmet Hospital, India

    *Corresponding author: Lalit M Srivastava, Professor, Consultant Advisor, Department of Biochemistry and Lab Medicine, Sir Ganga Ram Kolmet Hospital, Pusa Road, New Delhi-110005, India

Submission: February 21, 2018; Published: February 26, 2018

DOI: 10.31031/ACAM.2018.01.000517

ISSN: 2637-7802
Volume1 Issue4


The Complement System provides a rapid and efficient means to protect the host from invasive microorganisms. Due to its diverse biological activities, complement is the major mediator of inflammation, a natural response to the host tissue to any injury. Evidences are available to show that complement significantly contributes to the regulation of immune response. Furthermore, the effector functions arising from complement activation carry the potential for harming the host by directly or indirectly mediating inflammatory tissue destruction. Inappropriate or excessive activation of the complement system can lead to harmful, potentially life-threatening consequences due to severe inflammatory destruction. Genetic complement deficiencies or complement depletion have been found to be beneficial in reducing tissue injury of severe complement dependent inflammation. Considerable clinical and experimental evidence along with the work done in our laboratory implicate the role of complement.

Get access to the full text of this article