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Advancements in Bioequivalence & Bioavailability

In Silico Study on Tea Flavanoids as Anticlastogens

Submission: June 11, 2018; Published: August 08, 2018

DOI: 10.31031/ABB.2018.01.000520

ISSN 2640-9275
Volume1 Issue4


The interaction of flavonoids of tea extract with different histone proteins member of bone marrow of Swiss mice in silico were satisfactory, and all the interaction (Docking using Hex 5.1) were found to have very low entropy values indicative of strong interaction. Potassium dichromate which has been reported in literature as a potential clastogen was also tested for its activities and interaction with histones and it was found that the interaction of compound also yielded very low E- values. Different histone proteins were docking with flavonoids of tea extract at very first step to give some values and histone proteins docking with flavonoids of tea extract in presence of known clastogen (potassium dichromate) gave some values. From the values the study could suggest the flavonoinds were midly anticathodes.

Keywords: Flavonoids of tea extract; Histone protein; Docking; Anticlastogenic effectn

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