How Schizophrenia Could be Caused by Cholera & Ferric Chloride Disease

Cholera produces dehydration in its victims. I suspect that the survivors of cholera have their DNA damaged by the bacterium. The Adenine in DNA has a hydroxide ion an alcohol attached. It could be stripped off the cyclohexane to join to the Hydrogens from the acid (water is a weak acid) or the DNA itself. Perhaps the Iron replaces the hydrogen on the DNA molecule while Chlorine does the same for the hydroxide ion, the alcohol [1-4]. The damaged adenine has a chlorine and an iron in place of the Hydrogen and Hydroxide (Figure 1).

Figure 1:The damaged adenine has a chlorine and an iron in place of the hydrogen and hydroxide.

2FeCl₂+2HOH → 2FeOH+2HCl+Cl₂

Dehydration of Alcohol

C=C(H-OH) → HCl (ACID CATYLST) → H OH(WATER)

My original thesis had Ferric Chloride (FeCl₂) as the culprit causing schizophrenia [5,6]. Yet, cholera has a role too. This latest theory explains why iron laden water may lead to schizophrenia. It may also explain why schizophrenia is a northern hemisphere problem viz. Water supply systems using iron piping [7-9].

1. Cusack P (2017) Schizophrenia and its causes: Ferric chloride (Cusack’s) disease. Men Health Fam Med 2: 1-2.
2. Cusack P (2017) Mental illness and cholera. Men Health Fam Med 2: 1-2.
3. Cusack P (2017) More on the robust solution for epidemiology: Nineteenth century in Quebec. J Biomet Biostat 8: 1-2.
4. Cusack P (2017) Cholera, iron and mental illness in nineteenth century. J Biomet Biostat 8: 1-2.
5. Cusack PTE (2017) LSD, caffeine, and cholera: Possible causes of schizophrenia. J Mol Genet Med 11(4): 296.
6. Cusack PTE (2018) Chlorine, creosote and dementia. EC Psychology and Psychiatry 7(1): 11-12.
7. Cusack PTE (2018) SZ and its cause: Ferric chloride disease. PRAS.
8. Cusack PTE (2017) Dehydration: The cause of schizophrenia: Cholera, ferric chloride and caffeine. EC Psychology and Psychiatry 6(2): 89-90.
9. Cusack PTE (2017) More on cholera and schizophrenia: In Mauritius. American Journal of Biometrics and Biostatistics 1(1): 1-2.