Abstract

Aim of the study: The study aimed to clarify how to overcome streptokinase-induced hypotension during acute myocardial infarction intravenous infusion?
Background: Streptokinase is the cheapest approved thrombolytic agent. Streptokinase is commonly associated with hypotension. The delay in giving a thrombolytic agent for acute myocardial infarction may be hazardous.
Method of study and patients: My study was an observational-retrospective twenty-case report series. The study was conducted in Fraskour Central Hospital and Kafr El-Bateekh Central Hospital. The author reported twenty cases of confirmed acute myocardial infarction with indications for thrombolytic over about 34 months, starting on October 5, 2018, ended on July 25, 2021. Testing for the probability of hypotension during infusion of streptokinase was done for all cases. Three and One Method (Yasser’s Method) was only applied in the cases of hypotension during streptokinase intravenous infusion.
Results: The mean age in the current study is 60.6 with male sex predominance (85%). Acute inferior myocardial infarction is the most common (55%) infarction. Pre-testing for the probability of hypotension during infusion of streptokinase was only applied in (50%) with equal positive probability and negative probability test was (50%). Yasser’s Methods was applied in (75%) in response in (100%).
Conclusion: Three and One Method (Yasser’s Method) is an innovative clinical and therapeutic method in cardiovascular science. The method is used in cases of acute myocardial infarction. It is indicated in the cases of hypotension during the intravenous infusion of streptokinase. The Three and One Method (Yasser’s Method) is effective, safe, and time saving for cases of acute myocardial infarction.

Keywords: Three and one method; Yasser’s Method; Streptokinase; Hypotension; Myocardial infarction; Ischemic heart disease; Thrombolytic

Abbreviations:ABG: Arterial Blood Gases; AMI: Acute Myocardial Infarction; BP: Blood Pressure; CAS: Coronary Artery Spasm; CBC: Complete Blood Count; CCBs: Ca2+ Channel Blockers; ECG: Electrocardiography; ED: Emergency Department; EF: Ejection Fraction; GCS: Glasgow Coma Scale; HR: Heart Rate; ICU: Intensive Care Unit; IHD: Ischemic Heart Disease; IVI: Intravenous Infusion; LBBB; Left Bundle Branch Block; MI: Myocardial Infarctions; NSR: Normal Sinus Rhythm; O₂: Oxygen; PVCs: Premature Ventricular Contractions; RBBB: Right Bundle Branch Block; RBS: Random Blood Sugar; RR: Respiratory Rate; SCD: Sudden Cardiac Death; SK: Streptokinase; SK-hta: Streptokinase-Induced Hypotension; STEMI: ST-Elevation Myocardial Infarction; UA: Unstable Angina; VR: Ventricular Rate