Abstract

Cardiovascular Health (CVH) is a multifaceted outcome that is influenced by a complex interplay of genetic and environmental factors. Maternal nutrition during preconception and pregnancy is recognized as a crucial factor that affects cardiovascular health in offspring. This mini review provides an overview of the current scientific evidence supporting the impact of maternal nutrition on lifelong cardiovascular health across generations, with a particular emphasis on the epigenetic mechanisms involved. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, play a vital role in mediating the effects of maternal nutrition on cardiovascular outcomes. Several specific nutrients, such as folate, omega-3 fatty acids, and antioxidants, have been demonstrated to influence epigenetic modifications, thereby affecting gene expression patterns relevant to cardiovascular health. Intervention studies have demonstrated the potential to improve cardiovascular health through targeted maternal nutrition interventions. A comprehensive understanding of the intricate relationship between maternal nutrition, epigenetics, and cardiovascular health has critical implications for developing preventive strategies and personalized approaches to promote lifelong cardiovascular well-being. Further research is warranted to fully elucidate these mechanisms and inform public health policies and interventions.

Keywords:Cardiovascular health; Maternal nutrition; Epigenetics