1Tulane University School of Medicine, USA
2Tulane Cancer Center, USA
3Tulane University Radiation Oncology Department, USA
*Corresponding author:Alexander Suh, Tulane University School of Medicine, USA
Submission: February 08, 2024;Published: February 27, 2024
ISSN: 2578-0360Volume3 Issue4
Introduction: Corneal Melanoma (CM) is a rare malignancy that develops from melanocytes within
the cornea, constituting a minority of all ocular tumors. In this study, we sought to investigate the
clinicopathological characteristics correlated with the prognosis of CM patients.
Methods: We collected patients with CM between 1983 and 2018 from the Surveillance, Epidemiology,
and End Results (SEER) database. Cox proportional hazards regression was used for univariate analysis to
value Hazard Ratio (HR) of malignant CM versus spindle cell melanoma and nodular melanoma subgroups.
Results: A total of 29 eligible patients were collected in our study. Age at diagnosis, laterality, primary
site, tumor size, the extent of disease, marital status, income, residential area, and treatment showed no
significant prognostic factors for CM patients (P>0.05). However, when concerned with the primary site
of malignant melanoma, spindle cell melanoma (P<0.05) and nodular melanoma (P<0.05) were found to
show significantly poorer prognosis in CM patients.
Conclusion: Age at diagnosis, laterality, primary site, tumor size, the extent of disease, and treatment were
not significant prognostic indicators for CM patients. Spindle cell melanoma and nodular melanoma were
notable for showing worse survival outcomes than malignant melanoma. Although the sample size in the
SEER database was limited, our findings may provide motivation for tailoring individualized treatments
for patients with CM with different primary sites.